abstract：:Cell replacement therapy is of great interest as a long-term treatment of neurodegenerative diseases such as Parkinson's disease (PD). We have previously shown that Sertoli cells (SC) provide neurotrophic support to transplants of dopaminergic fetal neurons and NT2N neurons, derived from the human clonal precursors ce...

journal_title：Brain research bulletin

authors： Saporta S,Willing AE,Shamekh R,Bickford P,Paredes D,Cameron DF

更新日期：2004-12-15 00:00:00

abstract：:Cellular and molecular mechanisms involved in the generation of seizures and the magnitude of neural cells injury are not fully understood. We evaluated astrocyte and/or neuronal injury in rats in the pentylenetetrazol model of acute seizures by measuring S100B and NSE levels in cerebrospinal fluid. Additionally, we d...

journal_title：Brain research bulletin

authors： Oses JP,Leke R,Portela LV,Lara DR,Schmidt AP,Casali EA,Wofchuk S,Souza DO,Sarkis JJ

更新日期：2004-09-30 00:00:00

abstract：:Windup, the frequency dependent build-up of spinal neuronal responses is an electrophysiological model of the development of the central sensitization in the chronic pain states. NR2B subunit containing NMDA-type glutamate receptors are implicated in the windup of dorsal horn neurons, while their role at the motoneuro...

journal_title：Brain research bulletin

authors： Kocsis P,Kovács G,Farkas S,Horváth C,Szombathelyi Z,Tarnawa I

更新日期：2004-08-30 00:00:00

abstract：:A number of procedures exist for the experimental induction of sodium appetite. With the exception of a low sodium diet, nearly all of these methods are invasive, requiring injections, surgery, or both. In addition to stimulating intake of concentrated salt, some of them produce substantial side-effects like reduced f...

journal_title：Brain research bulletin

authors： Caloiero VG,Lundy RF

更新日期：2004-07-30 00:00:00

abstract：:A current response induced by superfusing adenosine was examined in substantia gelatinosa (SG) neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique. In 78% of the neurons examined, adenosine induced an outward current at -70 mV [18.8 +/- 1.1 pA (n = 98) at 1mM] in a dose-dependent mann...

journal_title：Brain research bulletin

authors： Liu T,Fujita T,Kawasaki Y,Kumamoto E

更新日期：2004-07-30 00:00:00

abstract：:The goal of this study was to determine if the dorsal noradrenergic bundle (DNAB) plays an essential role in mediating increased plasma renin activity (PRA) and hypothalamic activation, as indicated by increased Fos expression, in response to a small volume blood loss in unanesthetized animals. Male Sprague-Dawley rat...

journal_title：Brain research bulletin

authors： Jaworski RL,Blair ML

更新日期：2004-07-15 00:00:00

abstract：:Sleepiness and driving is a dangerous combination that causes thousands of crashes each year resulting in injury and death. In the last few years, driving simulators have been used to study the performance decrements associated with drowsiness. We correlated performances of a driving simulation task in healthy volunte...

journal_title：Brain research bulletin

authors： Pizza F,Contardi S,Mostacci B,Mondini S,Cirignotta F

更新日期：2004-06-30 00:00:00

abstract：:Prenatal exposure of mice to heroin (SC injection of 10mg/kg to the dams on gestational days 9-18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergic innervation accompanied with both presynaptic and postsynaptic cholinergic hyperactivity; including an increase membrane PKC activity, ...

journal_title：Brain research bulletin

authors： Yaniv SP,Naor Z,Yanai J

更新日期：2004-05-30 00:00:00

abstract：:Previous studies suggest that hypnotizability represents a protective factor against the cardiac effects of cognitive stress and that hypnosis prevents vascular stress-induced modifications in highly hypnotizable individuals. The aim of the experiment was to investigate whether a similar effect at vascular level is pr...

journal_title：Brain research bulletin

authors： Jambrik Z,Santarcangelo EL,Ghelarducci B,Picano E,Sebastiani L

更新日期：2004-04-30 00:00:00

abstract：:Preprodynorphin and preproenkephalin are protein precursors from which are derived two classes of opioid neurotransmitter peptides. Dynorphin A((1-17)) is produced by proteolytic processing of prodynorphin, and processing of proenkephalin yields the enkephalin peptides. We report here on the isolation and sequencing o...

journal_title：Brain research bulletin

authors： LaForge KS,Nyberg F,Kreek MJ

更新日期：2004-03-15 00:00:00

abstract：:The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for contr...

journal_title：Brain research bulletin

authors： Butler TL,Pennypacker KR

更新日期：2004-03-01 00:00:00

abstract：:Glaucoma is no longer viewed simply as elevated intraocular pressure (IOP) that damages the optic nerve. In addition to high IOP, evidence is rapidly accumulating that suggests damage to the optic nerve may be initiated or sustained by any number of factors including ischemia, excitotoxicity, neurotrophin insufficienc...

journal_title：Brain research bulletin

authors： Tezel G,Yang J,Wax MB

更新日期：2004-02-15 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over 60 years of age in the US and many other developed countries. Increasingly sophisticated methods for the diagnosis and treatment of macular degeneration are not effective for the majority of patients in whom late stage...

journal_title：Brain research bulletin

authors： Rowe-Rendleman C,Glickman RD

更新日期：2004-02-15 00:00:00

abstract：:A substantial and still growing body of research tries to link different psychological models and chronic diseases, with special emphasis on cardiovascular disease. These efforts have established several conceptual bridges that connect psychological alterations and psychosocial factors to the risks, onset and prognosi...

journal_title：Brain research bulletin

authors： Kopp MS,Réthelyi J

更新日期：2004-02-01 00:00:00

abstract：:Brain cytokines have been implicated in brain plasticity and mood alterations. We present here the first evidence of a chronic stress-induced modulation of central cytokines, in absence of experimentally induced inflammatory processes. Several brain areas were extracted from stressed and control mice and cytokines mRN...

journal_title：Brain research bulletin

authors： Bartolomucci A,Palanza P,Parmigiani S,Pederzani T,Merlot E,Neveu PJ,Dantzer R

更新日期：2003-12-30 00:00:00

abstract：:Previously, we have showed that the cholecystokinin (CCK)-A receptor expression in hypothalamus is closely related with the responsiveness of electroacupuncture (EA)-mediated analgesic effects in rats. In order to confirm this observation more directly in vivo, the EA-mediated analgesic effects are compared between Ot...

journal_title：Brain research bulletin

authors： Lee GS,Han JB,Shin MK,Hong MC,Kim SW,Min BI,Bae H

更新日期：2003-12-15 00:00:00

abstract：:The effects of post-training intra-hippocampal injections of group I mGluR agonists and antagonists, were examined in the contextual fear test, in rats. It was found that (S)-3,5-dihydroxyphenylglycine (DHPG) (a mGluR1-5 agonist) decreased, and (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) (a mGluR1 antagonist) incre...

journal_title：Brain research bulletin

authors： Maciejak P,Taracha E,Lehner M,Szyndler J,Bidziński A,Skórzewska A,Wisłowska A,Zienowicz M,Płaźnik A

更新日期：2003-11-15 00:00:00

abstract：:Neuroimaging studies in patients suffering from affective disorders have shown decreased volume and reduced regional cerebral blood flow in multiple areas of the prefrontal cortex, including the medial prefrontal cortex and the orbitofrontal cortex. This aberrant brain activity is among other things attributed to chro...

journal_title：Brain research bulletin

authors： Gerrits M,Westenbroek C,Fokkema DS,Jongsma ME,Den Boer JA,Ter Horst GJ

更新日期：2003-10-15 00:00:00

abstract：:Obesity and high fat diets are associated with an increased prevalence of diabetes, cardiovascular disease, and hypertension. However, the mechanism(s) linking obesity and high fat diet to these metabolic and cardiovascular disorders are not fully elucidated. Leptin stimulates the formation of pro-opiomelanocortin and...

journal_title：Brain research bulletin

authors： Barnes MJ,Lapanowski K,Conley A,Rafols JA,Jen KL,Dunbar JC

更新日期：2003-09-30 00:00:00

abstract：:Expression of the Huntington's disease (HD) mutation in mice (R6/2 line) causes a progressive neurological phenotype that includes deterioration of motor function resembling that seen in HD. The current study sought to determine whether or not chronic treatment of R6/2 mice with lithium chloride would have an effect o...

journal_title：Brain research bulletin

authors： Wood NI,Morton AJ

更新日期：2003-08-30 00:00:00

abstract：:The medial preoptic area is a key structure in the neural control of reproduction. Considerable evidence has accumulated indicating that glutamatergic innervation of the area plays an important role in this control. Sources of the glutamatergic input are unknown. Present investigations were aimed at studying this ques...

journal_title：Brain research bulletin

authors： Kocsis K,Kiss J,Csáki A,Halász B

更新日期：2003-08-30 00:00:00

abstract：:Polymerase chain reaction assays are a powerful tool for detecting the presence of infectious genomes in the cerebrospinal fluid. Positive results always mean a current or pending infection of the central nervous system. Subacute (>7 days) or chronic infections induce an intrathecal humoral immune response and the app...

journal_title：Brain research bulletin

authors： Sindic CJ,Van Antwerpen MP,Goffette S

更新日期：2003-08-15 00:00:00

abstract：:We studied mitochondria in the satellite cell sheaths which envelope the spinal ganglion neurons of rabbits aged 12, 42, and 79 months. While the mean cytoplasmic volume of satellite cell sheaths did not change significantly with age, the mean percentage of cytoplasmic volume occupied by mitochondria decreased with ag...

journal_title：Brain research bulletin

authors： Martinelli C,Sartori P,Ledda M,Pannese E

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND AND PURPOSE:In humans, activation of the diving reflex by a cold stimulus to the face results in bradycardia, peripheral vasoconstriction and an increase in blood pressure. However, responses of the cerebral blood flow have not yet been evaluated. We undertook this study to assess the effect of cold face sti...

journal_title：Brain research bulletin

authors： Brown CM,Sanya EO,Hilz MJ

更新日期：2003-06-30 00:00:00

abstract：:The vestibular nuclei and posterior cerebellum are the destination of vestibular primary afferents and the subject of this review. The vestibular nuclei include four major nuclei (medial, descending, superior and lateral). In addition, smaller vestibular nuclei include: Y-group, parasolitary nucleus, and nucleus inter...

journal_title：Brain research bulletin

authors： Barmack NH

更新日期：2003-06-15 00:00:00

abstract：:Small GTPases of the rho family regulate the extensive rearrangements of the cytoskeleton that characterize neuronal differentiation. Citron kinase is a target molecule for activated rhoA, previously implicated in control of cytokinesis. We have found that, in addition, it could play an important role in modulating th...

journal_title：Brain research bulletin

authors： Di Cunto F,Ferrara L,Curtetti R,Imarisio S,Guazzone S,Broccoli V,Bulfone A,Altruda F,Vercelli A,Silengo L

更新日期：2003-05-30 00:00:00

abstract：:Sexually relevant pheromonal cues are detected by the vomeronasal system which includes the posterodorsal part of the medial amygdala, the posteromedial part of the bed nucleus of the stria terminalis and the medial preoptic area. Copulatory behavior is impaired in mice lacking functional aromatase, the enzyme convert...

journal_title：Brain research bulletin

authors： Aste N,Honda S,Harada N

更新日期：2003-05-15 00:00:00

abstract：:Aged (25-27 months) Long-Evans female rats were distinguished according to whether they showed no significant impairment (AU), moderate impairment (AMI), or severe impairment (ASI) in a spatial reference-memory task. Young (3-5 months) rats served as controls. Electrically evoked overflow of tritium was assessed in hi...

journal_title：Brain research bulletin

authors： Birthelmer A,Stemmelin J,Jackisch R,Cassel JC

更新日期：2003-05-15 00:00:00

abstract：:Cognitive experimentation suggests that at any single instant only three or four items ("chunks") are simultaneously prominent as a working memory (WM) trace, if we disregard the rehearsal component of WM. The reason for small WM capacity may concern combinatorial manageability. How might the neural representations of...

journal_title：Brain research bulletin

authors： Glassman RB

更新日期：2003-04-15 00:00:00

abstract：OBJECTIVE:To establish a link between tryptophan (a precursor for 5-hydroxytryptamine (5-HT) or serotonin, involved in sleep and fatigue) and post-operative fatigue after major surgery. BACKGROUND:There is a link between tryptophan (the precursor for the neurotransmitter 5-hydroxytryptamine), and its competitive bindi...

journal_title：Brain research bulletin

authors： McGuire J,Ross GL,Price H,Mortensen N,Evans J,Castell LM

更新日期：2003-04-15 00:00:00

abstract：:The objective of this study was to determine the organization of coactivation in the arm and shoulder muscles. Normal human subjects made alternate movements of a joint in the horizontal plane, either adduction-abduction of the second finger and shoulder, ulnar-radial deviation of the wrist, or extension-flexion of th...

journal_title：Brain research bulletin

authors： Yamazaki Y,Suzuki M,Ohkuwa T,Itoh H

更新日期：2003-02-15 00:00:00

abstract：:Impairment of endosomal/lysosomal functions are reported as some of the earliest changes in several age-related neurological disorders such as Alzheimer's disease. Dysregulation of the lysosomal system is also accompanied by the accumulation of age-associated pigments and several recent reports have indicated that thi...

journal_title：Brain research bulletin

authors： Ditaranto-Desimone K,Saito M,Tekirian TL,Saito M,Berg M,Dubowchik G,Soreghan B,Thomas S,Marks N,Yang AJ

更新日期：2003-02-15 00:00:00

abstract：:Central nervous system habituation in humans was studied using functional magnetic resonance imaging and repeated presentations of single fearful and neutral faces. Habituation of blood-oxygenation-level-dependent (BOLD) signal during exposure to face stimuli, collapsed over fearful and neutral expressions, was eviden...

journal_title：Brain research bulletin

authors： Fischer H,Wright CI,Whalen PJ,McInerney SC,Shin LM,Rauch SL

更新日期：2003-01-30 00:00:00

abstract：:The non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) attenuates morphine-induced immediate-early gene expression in the rat striatum in a sexually dimorphic manner that depends in part on gonadal steroids. To determine if this effect was dependent on modulation of glutamate receptor...

journal_title：Brain research bulletin

authors： D'Souza DN,Harlan RE,Garcia MM

更新日期：2003-01-15 00:00:00

abstract：:Intrathecal grafting of cells as biological pumps to deliver monoamines, endorphins, and/or trophic factors, has been shown to be effective in treating chronic pain both in experimental animals and in clinical trials. We have tested whether intrathecal implantation of neuroblastoma cells reduces heat hyperalgesia and ...

journal_title：Brain research bulletin

authors： De la Calle JL,Mena MA,González-Escalada JR,Paíno CL

更新日期：2002-11-30 00:00:00

abstract：:We studied the effects of estradiol (E2) and progesterone (P) on progesterone receptor (PR) isoforms gene expression in the brain of ovariectomised female and gonadectomised male rats by RT-PCR analysis. In female rats, the expression of both PR isoforms was induced by E2 and down-regulated by P in the hypothalamus, w...

journal_title：Brain research bulletin

authors： Guerra-Araiza C,Coyoy-Salgado A,Camacho-Arroyo I

更新日期：2002-10-30 00:00:00

abstract：:Vestibular-evoked myogenic potentials (VEMPs), elicited by acoustic stimulation, have been proposed in the assessment of the vestibulo-cervical reflex pathways. The procedure has been previously validated in several otovestibular disorders. The aim of this study was to investigate patients affected by multiple scleros...

journal_title：Brain research bulletin

authors： Sartucci F,Logi F

更新日期：2002-10-15 00:00:00

abstract：:Phase and amplitude depth profiles of EEG theta-like activity (TLA) induced by bath perfusion of 50 micro M of the cholinergic agonist carbachol were investigated using rat hippocampal formation slices. The data showed that the amplitude and phase of laminar profiles of TLA recorded in vitro were the same as the type ...

journal_title：Brain research bulletin

authors： Kowalczyk T,Konopacki J

更新日期：2002-09-30 00:00:00

abstract：:The effects of separate and simultaneous recombinant bovine (rb) activin A and buserelin administration on the FSH release and pituitary FSH beta subunit gene expression in vivo were examined in ovariectomised, estradiol pretreated rats. The animals received a single injection of either rb activin A (50 ng), buserelin...

journal_title：Brain research bulletin

authors： Gajewska A,Siawrys G,Bogacka I,Przala J,Lerrant Y,Counis R,Kochman K

更新日期：2002-09-15 00:00:00

abstract：:In alpha-chloralose-anesthetized Sprague-Dawley (SD) rats with unilateral nucleus tractus solitarius (NTS) lesions, injection of the alpha(1)-adrenergic receptor agonist phenylephrine into the contralateral NTS dose-dependently increased arterial pressure (AP). Bunazosin (0.1 nmol) or prazosin (0.36 nmol), an alpha(1)...

journal_title：Brain research bulletin

authors： Tsukamoto K,Ito S,Katsunuma N,Hiratsuka M,Masubuchi Y,Kanai T,Kawabe T,Yajima Y,Kanmatsuse K

更新日期：2002-08-15 00:00:00